What is 5-MeO-DiPT? 5-MeO-DiPT, also known as "Foxy" or "Foxy Methoxy", is a synthetic psychedelic tryptamine drug. It is the methoxy derivative of diisopropyltryptamine (DiPT). According to our Rapid Street Reporting survey, between November 2021 and November 2023, only 6 participants reported use in the last 12 months out of 6,122 people surveyed.

What was found? Analysis of online discussions indicates that interest in and use of 5-MeO-DiPT has increased in an erratic but rising manner over the past 9 years. The most recent spike in discussion of the drug has been progressing since early 2024.

How is it being discussed? Reddit users report that 5-MeO-DiPT produces effects similar to MDMA at low doses and intense hallucinations at higher doses. It is often mentioned as a sex enhancer. 5-MeO-DiPT has a reputation as an intense, and unique psychedelic. Commenters frequently warn that 5-MeO-DiPT has a very steep dose-response curve, where even small dosage increases can intensify effects dramatically.
Many Reddit users report an uncomfortable body load on 5-MeO-DiPT, including nausea, vomiting, agitation, and a "weird" physical sensation. The onset of action is described as slow, leading some Reddit users to mistakenly re-dose and end up with an overly intense experience. At high doses, some commenters report excessively low blood pressure or elevated heart rate.

Drug Terms: 5-MeO-DiPT, Foxy, Foxy Methoxy

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A recently published study led by NDEWS Scientific Advisory Group member Dr. Daniel Ciccarone conducted semi-structured interviews and captured visual data from participants recruited from syringe service programs to understand the beliefs and behaviors surrounding the rise of fentanyl smoking culture in San Francisco. Visual data included video-recorded smoking sequences, photography, and daily field notes. The results showed that difficulty injecting and fear of overdose motivated transitions from injecting to smoking fentanyl. Foil was the most commonly used smoking material. Participants noted that they could gauge potency upon inhalation and developed techniques to regulate dosage. Participants also reported fentanyl ‘residue’ or ‘resin’ that remained on the smoking equipment, accumulating over time. Some participants found this ‘resin’ so desirable that they collected it in containers. Read the study here.

A recently published study compared harm reduction and overdose response services between community-based organizations (CBOs) and public health department (DPH) syringe service programs (SSP). Using the National Survey of Syringe Service Program four outcomes were examined: syringe distribution, naloxone distribution, fentanyl test strip availability, and buprenorphine implementation. The results showed that CBO SSPs with government funding had significantly higher provision of all four syringe and overdose response services compared to CPH SSPs. Read the study here.

A study published in the Journal of Analytical Toxicology reported the detection of clobromazolam in Australian emergency department intoxications. The authors note this is the first case series published in the literature concerning clobromazolam in clinical patients.

Our Web Monitoring team completed a search query for this drug this week, and clobromazolam has only been mentioned in 5 submissions in the past two years on Reddit. Read the study here.

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