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Substance use in the past 12 months: Phoenix, AZ (September 22–24, 2023)
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The Rapid Street Reporting (RSR) team visited Phoenix, AZ on September
22–24, 2023 and surveyed 363 individuals. After alcohol and marijuana, the next most commonly reported substances used in the past 12 months were psilocybin (11.6%), delta-8-THC (8.0%), and delta-10-THC (5.2%). Read the report here. |
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NDEWS Hotspot Alerts: 21 counties with higher-than-expected drug-related 911 dispatch counts
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Joint INTREPID Laboratory releases priority project: Sourcing xylazine
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Last week, the Drug Enforcement Administration (DEA), US Customs and Border Protection (CBP), and US Food and Drug Administration (FDA)––working collaboratively as the Joint Intelligence National Threat Response – El Paso Illicit Drug Lab (Joint INTREPID Laboratory)––released a report on sourcing xylazine. INTREPID confirmed that both liquid veterinary preparations and powder xylazine are being used to adulterate fentanyl and has observed chemical markers in xylazine seizures that can assist in determining precursors, synthetic routes, and potentially connecting cases. Read the report here. |
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Xylazine potentiates the lethal but not the rewarding effects of fentanyl in mice
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A study recently published in Drug and Alcohol Dependence examined the preclinical rewarding and lethal effects of fentanyl combined with xylazine and the efficacy of naloxone or yohimbine to prevent death. At the doses tested, the authors found that xylazine did not modify fentanyl’s rewarding effects during the conditioned-place preference test in mice, but xylazine increased the lethality induced by fentanyl. Naloxone, but not yohimbine, effectively prevented the lethality of the fentanyl/xylazine combinations in both male and female mice. Read the study here. |
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Schedules of controlled substances: Temporary placement of N-desethyl isotonitazene and N-piperidinyl etonitazene in Schedule I of the Controlled Substances Act
This week, the DEA temporarily placed two benzimidazole-opioids––N-desethyl isotonitazene and N-piperidinyl etonitazene––in Schedule I of the Controlled Substances Act. Read the proposed rule here. |
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